Relationship between 5-fluorouracil (5-FU) dose intensity and therapeutic response in patients with advanced colorectal cancer receiving infusional therapy containing 5-FU
نویسندگان
چکیده
منابع مشابه
Measurements of 5-FU Plasma Concentrations in Patients with Gastrointestinal Cancer: 5-FU Levels Reflect the 5-FU Dose Applied
Introduction: 5-Fluorouracil (5-FU) is the basis of most combination chemotherapies for gastrointestinal tumors. It is generally well tolerated, but side-effects might require dose-adjustment. As adverse events are not specific to the 5-FU component of the chemotherapy-combination, i.e. neutropenia, diarrhea or cardiotoxicity, the knowledge of 5-FU serum levels might help to attribute these sid...
متن کامل5-FU schedules, serum 5-FU levels and their relationship to therapy response and toxicity in patients with gastrointestinal cancer.
Correspondence to Dr. Silke Cameron, MD Department of Gastroenterology and Endocrinology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany silke.cameron@med. uni-goettingen.de
متن کاملEffect of Skimmed Milk on the Absorption and Metabolism of 5-Fluorouracil (5-FU) in Animals
Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits. Plasma concentration of both 5-FU and its metabolit...
متن کاملEffect of Skimmed Milk on the Absorption and Metabolism of 5-Fluorouracil (5-FU) in Animals
Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits. Plasma concentration of both 5-FU and its metabolit...
متن کاملPhase I study of docetaxel (TXT) and 5-fluorouracil (5-FU) with concurrent radiotherapy in patients with advanced esophageal cancer.
UNLABELLED This phase I study was designed to determine the maximum-tolerated dose (MTD) of docetaxel (TXT) and toxicities of combining weekly administration of TXT and continuous infusion of 5-fluorouracil (5-FU) with concomitant radiotherapy for advanced esophageal cancer. PATIENTS AND METHODS Patients received TXT by i.v. infusion over 1 h on days 1, 8, 22 and 29. They were also given 5-FU...
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ژورنال
عنوان ژورنال: Cancer
سال: 1996
ISSN: 0008-543X,1097-0142
DOI: 10.1002/(sici)1097-0142(19960201)77:3<441::aid-cncr4>3.0.co;2-n